December 30, 2011

Expressing Type 2 Diabetes in your DNA

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Researchers have found the first sign that a person may develop type 2 diabetes. it’s not something visible in your DNA sequencing of the nucleotides. Diabetes may be something in the gene expression of the nucleotides making up your DNA.

A recent finding at Hebrew University of Jerusalem found am “early warning” sign that could lead to new approaches to treating type 2 diabetes. Before this discovery, researchers thought that small molecular marks on the structure of DNA increased the chances of developing type 2 diabetes but direct evidence was missing.

This novel technique involves mapping variations in DNA sequences. A proof-of-concept study showed evidence of a “signature” in the DNA  that is undeniably disease-predisposing. This is the first report of this type of risk factor for type 2 diabetes.

More specifically – these are defects in the creation of DNA molecules that affect the gene expression but do not change the sequence of nucleotides. This defects cause several types of diseases that afflict humans.

This identifiable “signature” found in the DNA sequence may be a good indicator of how to proactively treat impaired glucose metabolism, even before signs of diabetes require diagnosis.

These findings may lead to the understanding of similar mechanisms in a long list of common human diseases, including many metabolic, autoimmune and psychiatric disorders.

Diet, exercise, family history, and other obvious factors have been the go to for predisposition to type 2 diabetes. With the findings of this study – we may be able to utilize the insight of gene expression to enact the foresight necessary to evade the misfortune of type 2 diabetes.

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