February 12, 2013

Impairment of the Immune System in T1D

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immune_t1dHaving a hearing or sight impairment is clearly the influence of the ears or eyes. But impaired immune system? Where do you pin the culprit of this deficiency?

People with T1D have no problem fighting infection or any of the immune system  requirements herein. It just seems that we have a dysfunction when identifying things specifically that look a lot like pancreatic beta cells.

A study has identified the immune system for its impairment for this very reason. A question for the study looked outside the box.  The researchers wanted to know if if was the B cells (beta cells) or the T-cells (immune cells) that cause T1D.

The summary of the study says “while T1DM is fundamentally a T-cell-mediated autoimmune response, the development of this disease results from complex interactions between the adaptive and innate immune systems,”.

A few years ago, Barbara David Center for Childhood Diabetes published a study identifying insulin as the autoantigen in the development of Type 1 diabetes.

Science is a funny thing. You can play around with statistics and numbers to support or deny a fact. But at the end of the day, a fact is a fact. In 2011, insulin was identified as a key player in  the development T1D. In 2013, insulin was identified as a supporting factor  in T1D.

It’s a fact that the body creates insulin. How can the body mistakenly ID an endogenous hormone as a foreign body? The immune system is, in fact, impaired.

Stay tuned for the story on T1D being cured in dogs due to gene therapy. This may be what is needed to retrain our genetic predisposition to destroying insulin producing cells.

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