July 18, 2013

Russia may be the Reason I have T1D

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solid-foodsThe approximate time of first exposure to solid food for infants appears to be associated with the development of T1D, according to the DAISY Study, published in JAMA Pediatrics.

The conclusion of the DAISY Study is attention grabbing. In children at increased genetic risk for T1D, the safest age to introduce solid foods is between 4 and 5 months of age.

Genetic predisposition to T1D includes a first-degree family history of T1D and  newborn screening for human leukocyte antigen (HLA) that can lead to insulin-producing cell death.

The incidence of T1D is increasing worldwide, with the most rapid increase among children younger than 5 years of age. The DAISY Study aimed to identify the associations between environmental exposures, especially early infant diet, and the development of T1D.

DAISY stands for Diabetes Autoimmunity Study in the Young. The study is a longitudinal, observational study conducted at St. Joseph’s Hospital in Denver, Colorado.

A total of 1835 children at increased genetic risk for T1D followed up from birth with complete prospective assessment of infant diet. Throughout the study, 2.3% or 53 children developed T1D.

Of the children that developed T1D, the first exposure to solid foods was of significance in the autoimmune attack leading to diagnosisInfants younger than 4 months of age and equal to or greater than 6 months of age compared with infants first exposed at 4 to 5 months of age, developed T1D.

This study resonates with me because my parents went to Russia within 4 months after I was born, March 31. Really? Russia over a newborn? From Russia, With Love.

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