April 2, 2013

Seeing Stress in Diabetic Retinopathy

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eye-stressNew research is investigating the role inflammation plays in the development of diabetic retinopathy.

The search is being conducted to see how endoplasmic reticulum (ER) stress can affect the eye condition.

Diabetes can affect the formation of cells in the body. Most prevalent is the abnormal cell growth in the eye.Researchers are studying stressed ER and how it may lead to the abnormal cell growth in the eye

The hypothesis alludes to the stress on the vascular development in the eye leading to inflammation.The researchers are testing potential therapies involving X-box binding protein 1. Remember Less X-box More Glucose Troubles in T2D?

In the earlier years of diabetes, this stressed ER is mildly present. However as the years progress, the stress begins to take its toll in the retina. The protective signaling in the body begins to diminish and the microvascular complications in diabetes begin to increase.

Genetically engineered mice will help the researchers determine if XBP-1 can successfully block the onset or progression of diabetic retinopathy. By age 40, an estimated 40% of American with diabetes have some form of diabetic retinopathy. X-box may be the salvation for diabetic retinopathy.

Have you seen the banned X-box commercial that says “life is short. Play more”? Although the demographic for the commercial is gamers, the commercial actually makes a good point for XBP-1.

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