January 3, 2012

The Matrix and Kidney Damage in Diabetes

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As a result of elevated glucose in the blood, certain proteins are manufactured and scar the tissues in the kidney. Researchers found that adding sodium hydrosulfide decreased the production of these damaging proteins despite the high concentration of glucose.

It was also found that the naturally occurring enzymes that assist in the manufacturing of hydrogen sulfide were reduced in the mice with diabetes, type 1 and type 2. The difference between sodium hydrosulfide and hydrogen sulfide is a matter of a laboratory engineered or naturally occurring means of preventing the damaging proteins from being created. Sodium hydrosulfide is the chemical compound that raises the levels of hydrogen sulfide in the body.

The process that creates this damaging protein is called matrix protein synthesis. Leave it to the Matrix to create something damaging.  However the researchers have found a way to decrease matrix protein synthesis in diabetes.

Before we rejoice in the findings of this study – we must know that the current work is being done on mice and must be transferred to humans for the effective treatment of kidney disease. FYI – hydrogen sulfide, at higher concentrations, is known to be a toxic agent. Not to mention hydrogen sulfide is also known as sewer gas.

For more details on the study, please see the abstract on the Journal of Biological Chemistry.

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