December 28, 2012

The Race Against Prediabetes

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prediabetesPrediabetes is a condition where blood glucose levels are higher than normal but not yet high enough to be diagnosed as diabetes. The exact cause of the full-blown disease is still unclear but research has begun to pinpoint the catalyst to push prediabetes to Type 2 diabetes.

Many people believe that obesity is the #1 risk factor for Type 2 diabetes, but only 2-13% of people with obesity will ever develop the disease. However as many as 70% of people with prediabetes will develop Type 2 diabetes.

Impaired fasting glucose (IFG) is a telltale sign of prediabetes. IFG is due to an imbalance in glucose sensing in the body. Is the imbalance due to spirited liver, delivering too much glycogen or sluggish islets, not delivering enough insulin to control blood glucose levels?

The enzyme that helps sense the glucose in the body is glucokinase. The researchers believe that this failure to sense high glucose is due to a defect in glucokinase.  The study hopes to show that by enhancing glucokinase activity prediabetes will be reserved.

The study is currently ongoing and expected to end in June 2014. Hopefully by that time the nearly 80 million Americans with prediabetes will be breathing a sigh of relief knowing that their glucokinase is one  step closer to winning the race against prediabetes.

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