January 17, 2014

T1D Development Speed

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speedWhy is it some people develop T1D slowly whereas other people develop T1D like gas to a flame? Researchers investigated this phenomenon and published the study in Medical Xpress.

Researchers have identified a unique group of first degree relatives of people with T1D  who are a high risk of diabetes because they have had at least two islet autoantibodies in their blood for more than ten years but have not developed the disease.

Researchers are trying to identify people with slow progression T1D in existing studies.The researchers will carry out a series of tests to help understand why this group is relatively protected from the clinical signs of diabetes.

Dr. Kathleen Gillespie, a leading researcher in the study, said “it is well established that the presence of two or more islet autoantibodies in the blood is a very accurate marker for future type 1 diabetes. Yet some “at risk” individuals remain diabetes-free for decades.

“The aim of our study is to identify how the onset of diabetes is delayed for many years in some individuals. We believe that understanding the nature of this protection will ultimately help protect others.”

Blood tests are required to measure T cell function . The identifiable insulin autoantibodies are: IA, IA-2, and GAD65. Islet cell autoantibodies or ICA attack the cytoplasm of the islet cells whereas the aforementioned 3 attack the insulin, itself.

If an ICA attacks the islet itself, it demolishes the capabilities of the body to produce c-peptide. Research has shown that c-peptide has protective effects that allows mitigation of the autoimmune attack. I wonder if ICA spurs the autoimmune attack and plain old insulin autoantibodies delay it?

Unlike a catalyst, which speeds up the process of a reaction, this study is designed to identify the speed traps in T1D and find a way to slow them down the pathogenesis of the autoimmune attack.

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