December 8, 2009

Dr. Juan Bendala of DRI

by



kerry says to (16:46):
I’m thinking the DRI should be transplanted to India, Australia, Israel or somewhere where they allow stem cell research to continue unhampered.

kerry says to (16:47):
I am only half joking!

DRI CheerLeader says to (16:47):
I think DRI collaborates with researchers in other countries

kerry says to (16:48):
Yes, I know they do. Isn’t FLA trying to pass a law to prevent all stem cell research from taking place in the state?

*** (16:49):Welcome to Dr. Juan Bendala Chat , bp !

gina says (16:49):
i really dont understand why they wont allow it

gina says (16:49):
hi bp

DRI CheerLeader says to (16:49):
I wouldn’t be surprised – as one Bush left office
*** (16:50):Welcome to Dr. Juan Bendala Chat , Dr. Juan Bendala !

kerry says to (16:50):
We still have to wait for a Dem to be elected Pres. and perhaps a year or so after that to change legislation federally.

gina says (16:51):
Hello Dr. Bendala

DRI CheerLeader says to (16:51):
It seems the subject isn’t in the news so much anymore

Dr. Juan Bendala says to (16:51):
Hello. I just logged in.

gina says (16:51):
WElcome!
Dr. Juan Bendala says to (16:52):
Thanks!

kerry says to (16:52):
Isn’t in the news because it is a lost cause unless a Dem gets elected Pres.

DRI CheerLeader says to (16:52):
Hi Dr. Juan DB

Dr. Juan Bendala says to (16:52):
Hello everybody

gina says (16:52):
the chat will start in like 10 minutes

kerry says to (16:52):
Welcome, Dr. Bendala.

gina says (16:52):
officially

Dr. Juan Bendala says to (16:52):
We’ll wait until then

DRI CheerLeader says to (16:52):
I think we have to keep it in the news – ask for articles to be written

gina says (16:52):
you can still chat though

*** (16:52):Welcome to Dr. Juan Bendala Chat , jonhedrich !

Dr. Juan Bendala says to (16:52):
let’s chat, then!

DRI CheerLeader says to (16:52):
I don’t know if I can wait 10 minutes LOL:D

gina says (16:53):
well

gina says (16:53):
i will ask how is the weather in miami today!

Dr. Juan Bendala says to (16:53):
humid, hot… the usual

DRI CheerLeader says to (16:53):
Dr. Juan – what is the status of stem cell research in the state of Florida? Are they trying to ban it or just not support any public funding?

*** (16:53):Welcome to Dr. Juan Bendala Chat , allysmomma !

gina says (16:53):
You probably dont remember but i met you in miami in 2004!

*** (16:54):allysmomma quit the room

Dr. Juan Bendala says to (16:54):
I am not sure about that. What I know is that the DRI will keep doing work on embryonic stem cells no matter what the legislation is. I don’t think a ban will happen. They may ban the use of State funds, but that’s another story

DRI CheerLeader says to (16:54):
I didn’t vote for Bush or Charlie Christ

Dr. Juan Bendala says to (16:54):
Hello, Gina… perhaps you can refresh my memory

gina says (16:56):
You were the only scientist at the DRI there that day… August 2004… you were there for the tour i was on with gary

Dr. Juan Bendala says to (16:56):
Well, all the tours are with gary… but I am sure that if I saw you I would remember.

DRI CheerLeader says to (16:56):
She’s the hot one.

*** (16:56):Welcome to Dr. Juan Bendala Chat , BadShoe !
*** (16:57):Welcome to Dr. Juan Bendala Chat , grossman9318 !

DRI CheerLeader says to (16:57):
Oh sorry about that emotion thing

Dr. Juan Bendala says to (16:57):
It’s all right, I liked it

gina says (16:58):
that was so weird haha

DRI CheerLeader says to (16:58):
So what’s new in stem cell research at DRI? When asked, I request that people direct their donations to your lab.

*** (16:58):Welcome to Dr. Juan Bendala Chat , glorijeff !
*** (16:59):Welcome to Dr. Juan Bendala Chat , yd !

Dr. Juan Bendala says to (16:59):
I appreciate that very much. But all the work we do at the DRI is important, not just that in my lab. We are attacking diabetes from every possible angle. The supply problem (which we are tackling with stem cells) is only one facet.

gina says to grossman9318 (private) (17:00):
hello

Dr. Juan Bendala says to (17:00):
Immunological tolerance, for isntance, is as important. we wnat to replace the missing cells once and for all. The body must learn to recognize the transplanted cells as “self”, and not reject them again and again.

grossman9318 says to gina (private) (17:00):
hello gina

Dr. Juan Bendala says to (17:00):
In our lab we are presently working with a variety of stem cells, both adult and embryonic. Both have pros and cons. We want to cover our backs and not put all the eggs in one basket.

*** (17:01):Welcome to Dr. Juan Bendala Chat , AllieB2 !

kerry says to (17:01):
Does the recent discovery of Drs. Trivedi and Vanikar from Ahmedabad regarding mesenchymal cells (which will protect transplanted cells from being rejected) have an impact on your research?

Dr. Juan Bendala says to (17:02):
The idea is to expand these stem cells… which they do quite well by themselves. From one single vial of embryonic stem cells we can get billions of them in a matter of days. The challenge is not expanding them, but differentiating them along the beta cel

Dr. Juan Bendala says to (17:02):
…beta cell lineage.

DRI CheerLeader says to (17:02):
Have you managed to produce any cells that are glucose responsive?

Dr. Juan Bendala says to (17:02):
They don’t like to become beta cells… if given the choice, they’ll rather become neurons or heart tissue. We must educate them against their will to become beta cells.

*** (17:03):Welcome to Dr. Juan Bendala Chat , BetterCell !
gina (17:03):
How do you do that?

DRI CheerLeader says to (17:03):
You have to make them an offer they can’t refuse

gina says (17:03):
lol

kerry says to (17:03):
LOL

Dr. Juan Bendala says to (17:03):
We’ve got cells that have all the chartacteristics of pancreatic progenitor cells. In other words, they have an immature beta cell signature. New advances in our lab are shaping new ways to mature them. For instance, what we call “the oxygen sandwich”

bp says to (17:04):
Not able to stay for the entire chat.

Dr. Juan Bendala says to (17:04):
The idea is simple. We don’t want to reinvent the wheel. nature makes beta cells very well.

gina says to bp (private) (17:05):
thats ok i will have a chat transcript of this entire chat tomorrow

Dr. Juan Bendala says to (17:05):
We need to mimic nature. And one thing that nature does is to bathe stem cells in oxygen if they are to become beta cells. Islets are only 1 % of the pancreas, but they receive more than 25% of the total blood flow (and therefore oxygen) to the organ.

Dr. Juan Bendala says to (17:05):
Nobody thought that oxygen could be so important to differentiate stem cells into islets. But we have made a major breakthrough with a new system of our invention.

Dr. Juan Bendala says to (17:06):
By placing stem cells in these “oxygen sandwiches”, which are special petri dishes where cells receive air borth from the top and the bottom, they became beta cells 100-fold more efficiently than in regular dishes.

AllieB2 says to (17:06):
does the pH surrounding the islet transplant location have much to do with the success rate?

BetterCell says to (17:06):
O2 is needed for the creation and development fora ll life, which includes beta cells.

DRI CheerLeader says to (17:07):
So do you think some kind of oxygen deprivation occurs to kill off the islets in the pancreas ?

*** (17:07):Welcome to Dr. Juan Bendala Chat , Jeff !

AllieB2 says to (17:07):
pH imbalance can skew the ability to utilize oxygen effienently, can’t it?

Dr. Juan Bendala says to (17:07):
In type I diabetes, beta cells are destroyed by an autoimmune attack. But at the end of the day, diabetes damages blood vessels. Without healthy blood vessels, there is oxygen deprivation, so they will die more easily.

Dr. Juan Bendala says to (17:08):
Yes indeed.
*** (17:08):bp quit the room

Dr. Juan Bendala says to (17:09):
Most people around the world are trying to mimic only the molecular soup that leads to islet development. We are pioneering the recapitulation of a physiological environment (namely oxygen). We have found that the latter is as important, if not more.

Dr. Juan Bendala says to (17:09):
You are welcome to visit our lab and we’ll show you these devices. Our results have already been accepted for publication in a major journal and will be publicised shortly
BetterCell says to (17:09):

Dr. Bendala….which of all the current modalities being pursued do you think will come to be available for T1DM and Insulin Independence?

Dr. Juan Bendala says to (17:10):
Do you mean stem cell approaches, or in general?

BetterCell says to (17:10):
General in a clinical sense.

DRI CheerLeader says to (17:10):
I’d like to see a video on the DRI website – a virtual tour for those of us who cannot get down to Miami. Could that be done?

Dr. Juan Bendala says to (17:10):
About the video, I can see about that.

gina says (17:10):
that would be a great idea!

BadShoe says to BetterCell (17:10):
So what is to keep the autoimmune attack fro killing of any beta cell from stem cells?

Dr. Juan Bendala says to (17:10):
As for the strategies:

*** (17:11):Welcome to Dr. Juan Bendala Chat , Richard !

Dr. Juan Bendala says to (17:11):
Yes, that’s precisely the point. We have to put stem cell-derived beta cells, no doubt about that. But we also need to make the immune system prevent the attack.. Otherwise,. it will never end.

Dr. Juan Bendala says to (17:11):
And there are new approaches to do that.

BetterCell says to (17:11):
Modulation and desguies of those cells.

Dr. Juan Bendala says to (17:12):
Recently, a multidisciplinary team lead by our collaborator Julio Voltarelli, in Brazil, presented preliminary data showing that it might be possible to reset the immunological clock prior to the onset of the disease.

Dr. Juan Bendala says to (17:12):
Reprogram the autoimmune system, in toher words.

*** (17:12):Jeff quit the room

BadShoe says to BetterCell (17:12):
wow woul dthat reprogem work for things other than T1

BetterCell says to (17:13):
That does not benefit those of us w/T1DM already developed.

Dr. Juan Bendala says to (17:13):
The approach worked only in newly diagnosed patients, but 14 out of 15 patients got a complete reversal of the disease. very encouraging!!!

*** (17:13):lilkittykt quit the room
*** (17:13):Welcome to Dr. Juan Bendala Chat , lilkittykt !

DRI CheerLeader says to (17:13):
Is he the same Brazilian researcher who published last year and there was quite a bit of press including JAMA?

AllieB2 says to (17:13):
what was your opinion of the Brazilian approach to *knock out* the entire immune system before the stem cell transplant to *cure* Type 1 Diabetes? (earlier this year)

BetterCell says to (17:14):
That is too dangerous to do Allie.

DRI CheerLeader says to (17:14):
But some of them seemed to have LADA as I recall and didn’t they use immunosuppression?

Dr. Juan Bendala says to (17:14):
Yes, that is the problem. In order for this method to work, the body must have some residual beta cells that will replicate as soon as the autoimmune attack is blocked. That’s why, with Dr. Ricordi, we are now working on a double approach consisting in inf

kerry says to (17:14):
So if you cannot prevent autoimmune attack, transdifferentiation, training the liver, say to take on the job of the pancrease would only invite attack of the liver? If it could be done…

Dr. Juan Bendala says to (17:14):
…infusing stem cells and stropping the autoimmune attack.
*** (17:15):Welcome to Dr. Juan Bendala Chat , sixuntilme !

Dr. Juan Bendala says to (17:15):
Too many people at the same time. Sorry if I don’t get to you on time.

Dr. Juan Bendala says to (17:15):
This is indeed the brazilian study in JAMA. very controversial, because they didn’t have the appropiate controls. That’s why we are replicating it in a multinational study.

*** (17:16):lilkittykt quit the room
*** (17:16):Welcome to Dr. Juan Bendala Chat , lilkittykt !

DRI CheerLeader says to (17:16):
Are they communicating follow up data with you Dr. DB? Have the same people not relapsed?

Dr. Juan Bendala says to (17:16):
Transdifferentiation is indeed another startegy. Liver cells can be forced to produce insulin. They don’t do it as well as the islet, but… hey, they will escape the immune system. Your body is programmed to destroy beta cells, but these are liver cells.

AllieB2 says to (17:17):
Has your lab noticed if TNF-alpha has anything to do with the success rate of transplanted stem cells?

Dr. Juan Bendala says to (17:18):
We are in constant communication. Some people have relapsed, yes. It seems that the immune system cannot be fooled indefinitely. But this is only a first trial. More and more refined protocols will follow, and we are hopeful.

Dr. Juan Bendala says to (17:18):
And answering another question, yes, this method can also be used to treat other autoimmune disorders.

Dr. Juan Bendala says to (17:19):
TNF-alpha and inflammation go hand by hand. Inflammation will kill the islets upon transplantation, very quicly.

kerry says to (17:19):
Clinical trials are soon to take place in India regarding those cells which are back-up cells for insulin production and can be transplanted directly into the liver? Somehow, I don’t think the Indian version of the FDA will provide too much resistance.

Dr. Juan Bendala says to (17:19):
That’s why we need to follow a multidisciplinary approach. I make beta cells from stem cells.

DRI CheerLeader says to (17:19):
Well the Republicans cited that study all through the stem cell debate touting that diabetes had been cured using adult stem cells…while they left out all the details

Dr. Juan Bendala says to (17:19):
Other colleagues arrest the autoimmune response.

Dr. Juan Bendala says to (17:20):
Others tackle inflammation. We work as a team. A cure won’t come only from one discipline.

AllieB2 says to (17:21):
I agree with you, Dr. Dendala! The more information complied from *teams* of experts, the more everybody has to work with 🙂

*** (17:21):lilkittykt quit the room
*** (17:21):Welcome to Dr. Juan Bendala Chat , lilkittykt !
AllieB2 says to (17:21):
Bendala

DRI CheerLeader says to (17:21):
Would you be willing to comment on what you think of the encapsulated porcine islet transplants that are taking place in Russia in humans using LCT protocol?

Dr. Juan Bendala says to (17:21):
We must use all the tools in our hands. TWe welcome progress wherever it comes from, be it from adult or from embryonic stem cells. What they forgot to mention about the promise of these adult stem cells…

BetterCell says to (17:21):
I guess the Pharmaceurical Industry will not be very happy when the need for less Insulin becomes a Reality?

Dr. Juan Bendala says to (17:22):
is that it didn’t work at all in cases of long-standing diabetes. There, you need beta cell replacement in addition to adult stem cells for the immune system. And so far, the most promising at doing that are the embryonic.

Dr. Juan Bendala says to (17:23):
We are indeed pursuing encapsulation as a promising avenue of research. But the challenges are many. For one thing, encapsulation tends to choke the islets. And they need oxygen, as I mentioned above.

AllieB2 says to (17:23):
is it possible to harvest *embryonic* stem cells from the umbilical (sp?) cord?
*** (17:23):glorijeff quit the room

BadShoe says to BetterCell (17:23):
for a lay person what are the significant differances between embryonic and adult for making beta cells

Dr. Juan Bendala says to (17:23):
is it possible to harvest *embryonic* stem cells from the umbilical (sp?) NO

Dr. Juan Bendala says to (17:24):
uMBILICAL CORD CELLS, AGAINST COMMON WISDOM, ARE NOT EMBRYONIC. THEY ARE ADULT.

Dr. Juan Bendala says to (17:24):
THEY ARE EQUIVALENT TO THE BONE MARROW. GOOD FOR ARRESTING AUTOIMMUNE PROCESSES, BUT SO FAR THE EVIDENCE OF THEM TURNING INTO BETA CELLS IS VERY SCANT. BUT WE ARE ALSO LOOKING INTO THAT!

*** (17:24):Welcome to Dr. Juan Bendala Chat , bjphilly !
*** (17:24):Welcome to Dr. Juan Bendala Chat , StinkyHarriet !

Dr. Juan Bendala says to (17:24):
ADULT VS EMBRYONIC

BetterCell says to (17:25):
There ids more Differentation in Embryonic cells to take place. badshoe, I am not the guest Speaker. Thank you for the compliment though.

Dr. Juan Bendala says to (17:25):
EMBRYONIC STEM CELLS DIVIDE FOEREVER. YOU CAN GET BILLIONS IN DAYS. ADULT STEM CELLS DIVIDE A FEW TIMES AND THEN STOP.

Dr. Juan Bendala says to (17:25):
EMBRYONIC CELLS CAN BECOME ANY CELL TYPOE OF THE BODY. ADULT STEM CELLS, ONLY A HANDFUL.

Dr. Juan Bendala says to (17:25):
NO PANCREATIC ADULT STEM CELLS HAVE BEEN FOUND YET.

DRI CheerLeader says to (17:25):
Is there a risk of cancer developing from using embryonic stem cells?

Dr. Juan Bendala says to (17:26):
THERE IS A SMALL CHANCE. WE ARE CURRENTLY TRYING TO AVOID IT. ALLOW ME TO EXPLAIN.

BadShoe says to Dr. Juan Bendala (17:26):
so it like adults they get lazy and tired and the kids run forever wearing the adults out – lol

*** (17:27):Welcome to Dr. Juan Bendala Chat , tsmom !

Dr. Juan Bendala says to (17:27):
EMBRYONIC STEM CELLS DIVIDE ALL THE TIME, EXCEPT WHEN THEY DIFFERENTIATE. THEN THEY STOP. BUT WHAT IF ONE ROGUE STEM CELL DOES NOT DIFFERENTIATE, ONE IN A MILLION? IT COULD KEEP GROWING INSIDE THE PATIENT AND FORM A TUMOR CALLED TERATOMA.

Dr. Juan Bendala says to (17:27):
THAT’S WHY WE HAVE GENETICALLY ENGINEERED EMBRYONIC STEM CELLS SO THAT THEY CONTAIN TWO SUICIDE GENES.

Dr. Juan Bendala says to (17:27):
ONE OF THEM IS ACTIVATED WHEN THE CELL KEEPS DIVIDING AFTER TRANSPLANTATION. ONE ROGUE CELL IN A MILLION WILL SELF-DESTROY.NO QUESTIONS ASKED.

AllieB2 says to (17:27):
suicide genes — sounds *serious*!

kerry says to (17:28):
You guys think of everything, LOL! Wonderful!

Dr. Juan Bendala says to (17:28):
THE SCEOND SUICIDE GENE WILL ACTIVATE IF THE CELL BECOMES SOMETHING DIFFERENT FROM A BETA CELL (A NEURON, OR A HEPATOCYTE…). AGAIN, IF THE CELL DOESN’T GO IN THE DIRECTION WE WANT, IT WILL SELF-DESTROY./

BadShoe says to (17:28):
how do you do that

Dr. Juan Bendala says to (17:29):
WE PUT THESE GENES INTO ES CELLS. THEY JUST WAIT, SILENT… UNTIL THE CELL DOES SOMETHING BAD. THEN THEY BECOME ACTIVATED.

*** (17:29):bjphilly quit the room

Dr. Juan Bendala says to (17:30):
THIS IS ONLY ONE APPROACH, BUT IT IS NECESSARY. THE VERY SAME THING THAT MAKES ES CELLS SO APPEALING CAN ALSO BE A CURSE. BUT WE HAVE BEEN ABLE TO HARNESS THIS.

Dr. Juan Bendala says to (17:31):
PLUS, WE ARE MOVING ISLET TRANSPLANTATION TOWARDS THE USE OF SUBCUTANEOUS DEVICES. THERE, THE CELLS WILL BE ENTRAPPED AND NO POSSIBILITY OF TUMOR COULD EVER OCCUR. BUT IF THERE IS ONE POSSIBILITY IN A BILLION, WE WANT TO TAKE CARE OF THAT.

Dr. Juan Bendala says to (17:31):
NO MORE QUESTIONS?

BadShoe says to (17:32):
SUBCUTANEOUS DEVICES can you ‘explain what taht means

kerry says to (17:32):
Islet transplantation, will it ultimately be a therapy or a cure, or both?

Dr. Juan Bendala says to (17:32):
THEY ARE LITTLE CAPSULES THAT ARE IMPLANTED UNDER THE SKIN. WE LET THEM VASCULARIZE FOR A COUPLE OF WEEKS,. THEN WE INJECT THE ISLETS INTO THE DEVICE.

*** (17:33):StinkyHarriet quit the room

Dr. Juan Bendala says to (17:33):
THE ADVANTAGES ARE MANY-FOLD: YOU COULD DELIVER LOCAL IMMUNOSUPPRESION (INSTEAD OF SYSTEMIC) AND ISLES ARE EASILY ACCESIBLE.

Dr. Juan Bendala says to (17:33):
ISLET TRANSPLANTATION WILL BE A PART OF THE CURE. ULTIMATELY, HOWEVER, WE NEED TO TEACH THE IMMUNE SYSTEM NOT TO DESTROY THE BETA CELLS

Dr. Juan Bendala says to (17:34):
WE CALL IT TOLERANCE INDUCTION.

BadShoe says to (17:34):
so the islets would be in this “capsule”?

*** (17:34):Welcome to Dr. Juan Bendala Chat , Martin2043 !

gina says to Dr. Juan Bendala (17:34):
do you need anti rejection drugs still?
*** (17:34):yd quit the room

kerry says to (17:34):
I’m guessing no.

Dr. Juan Bendala says to (17:34):
YES. BUT IT IS NOT A MICROSCOPIC CAPSULE. IT IS MACROSCOPIC. WE ARE WORKING ON THIS. IT WILL PROBABLY BE THE FUTURE OF ISLET TX. REMEMBER, THE LIVER IS A BAD SITE.

BetterCell says to AllieB2 (17:34):
Dr Bendala……Can you give us a Time-Frame, when all this positive Stuff will be made available (at least in Human Trial)?

Dr. Juan Bendala says to (17:35):
HALF OF THE ISLETS DIE DURING ISOLATION. ANOTHER HALF OF THAT DIES UPON TX IN THE LIVER BECAUSE OF INFLAMMATORY PROCESSES. ONLY WHAT’S LEFT IS WHAT WORKS!

Dr. Juan Bendala says to (17:35):
YOU MAY NEED ANTI-REJECTION DRUGS… BUT LOCALLY, INSIDE THE DEVICE. NOT GENERAL. THAT WOULD BE A MAJOR BREAKTHROUGH.

Dr. Juan Bendala says to (17:36):
TIME FRAME

BetterCell says to AllieB2 (17:36):
Yes…

kerry says to (17:36):
Can enough islets be produced then as a therapy for all Type 1s or just selected few?

Dr. Juan Bendala says to (17:36):
IT IS DIFFICULT TO SAY, BUT I CAN TELL YOU THAT EMBRYONIC STEM CELLS ARE SCHEDULED TO BE USED IN THE FIRST HUMAN CLINICAL TRIUALS FOR THE END OF THIS YEAR. IT WILL BE FOR SPINAL CORD INJURY.

Dr. Juan Bendala says to (17:36):
RATS WITH SPINAL CORD INJURY WERE ABLE TO WALK AGAIN AFTER ES CELL TRANSPLANTATION.

Dr. Juan Bendala says to (17:36):
DIABETES WILL BE THE NEXT TO FOLLOW.

kerry says to (17:37):
Racehorses come before us! They are using it for the racehorses.

AllieB2 says to (17:37):
LOL

BetterCell says to AllieB2 (17:37):
Racehiorses are G-D’s Children as well.

AllieB2 says to (17:37):
lol

gina says (17:37):
lol

Dr. Juan Bendala says to (17:37):
WELL, IF THESE CELLS WERE TO HAVE AN UNEXPECTED SIDE EFFECTS, BETTER TO TRY THEM FIRST ON ANIMALS…

Dr. Juan Bendala says to (17:38):
BUT WE DON’T THINK SO.

kerry says to (17:38):
LOL

BadShoe says to (17:38):
yeah have you seen a trifecta hit?

Dr. Juan Bendala says to (17:38):
WE WON’T TRANSPLANT ES CELLS UNTIL WE PROVE THAT THEY ARE PERFECTLY SAFE. AND WE THINK THEY WILL BE.

gina says (17:38):
how do you know when they are safe?

kerry says to (17:38):
You do know how to cheer us all up!

Dr. Juan Bendala says to (17:39):
USING OUR SUICIDE GENE STRATEGY, THEY ARE 100% SAFE.

BetterCell says to AllieB2 (17:39):
Then I will no longer have to be concerned abouut getting enough of C-peptide, which Endogenous Insulin does not supply!!

gina says (17:39):
suicidal genes! that could be a r ock group lol

kerry says to (17:39):
I don’t expect miracles to happen overnight, but if miracles can happen, it may very well happen at the DRI.

Dr. Juan Bendala says to (17:39):
THIS IS A PROCESS, AND I KNOW THAT YOU ARE ALL IMPATIENT. I AM TOO! I JUST WANT TO CURE DIABETES AND THEN MOVE TO ANOTHER DISEASE!

gina says (17:39):
kerry i say that all the time!

gina says (17:40):
We cant help being impatient! Diabetes stinks….

BadShoe says to (17:40):
that could be a rock group lol Dave Berry

kerry says to (17:40):
This disease is so complicated, how can you put an immediate timeframe on it? But perhaps use of islet transplantation without immunosuppressants will be a good therapy in the meantime.

Dr. Juan Bendala says to (17:40):
ADVANCES IN STEM CELL RESEARCH ARE UNPRECENDENTED IN THE HISTORY OF SCIENCE. EVERY OTHER WEEK WE SEE AN IMPORTYANT BREAKTHROUGH.

BadShoe says to (17:40):
Where is a URL we can follow the progress

Dr. Juan Bendala says to (17:41):
DIABTES IS COMPLICATED. THAT’S WHY WE NEED TO WORK AS A TEAM, FROM STEM CELL BIOLOGISTS TO IMMUNOLOGISTS.

kerry says to (17:41):
I think we should all get out there and beat the bushes for money for the DRI. I will give New York Chapter a call.

*** (17:41):Martin2043 quit the room
gina says (17:42):
this is the link to the DRI website <a href=”http://www.diabetesresearch.org/”>http://www.diabetesresearch.org/</a>

DRI CheerLeader says to (17:42):
DRI is awesome – I’ve personally toured many times. The researchers are so approachable, dedicated, focused.

Dr. Juan Bendala says to (17:42):
ELIMINATING IMMUNOSUPPRESION WOULD BE A MAJOR BREAKTHROUGH. BUT STILL, WE ONLY GET A HADFUL OF PANCREATA EVERY YEAR, AND THERE ARE 18 MILLIOJN PEOPLE WITH T1D IN THE WORLD. WE ALSO NEED ALTERNATIVE SUPPLIES OF ISLETS.

*** (17:43):Welcome to Dr. Juan Bendala Chat , JB !

Dr. Juan Bendala says to (17:43):
YOU ARE ALL WELCOME TO TOUR THE DRI. WE’LL SHOW YOU EVERYTHING, FROM A STEM CELL TO AN ISLET.

gina says (17:43):
DR. B why do you think people develop type 1 later… for example i was 25 at diagnosis..

Dr. Juan Bendala says to (17:43):
WE WORK IN SUCHG A WAY THAT ANY PROMISING FINDING AT THE BASIC SCIENCE LEVEL CAN BE IMMEDIATELY TRANSLATED INTO CLINICAL THERAPIES.

BadShoe says to (17:43):
were is it

gina says (17:44):
badshoe DRI is in Miami

gina says (17:44):
near south beach….

Dr. Juan Bendala says to (17:44):
T1D IS VERY COMPLEX. WE DON’T KNOW MUCH ABOUT THE FACTORS THAT TRIGGER THE ONSET. SOME PEOPLE ARE GENETICALLY PREDISPOSED, BUT WON’T DEVELOP IT UNTIL AN ENVIRONMENTAL TRIGGER COMES.

BadShoe says to (17:44):
… well when yo put it that way…

gina says (17:45):
i dont know even know what would have t riggered it…

*** (17:45):Welcome to Dr. Juan Bendala Chat , anderdn !

Dr. Juan Bendala says to (17:46):
IN MICE PREDISPOSED TO DIABETES, THERE ARE MORE THAN A HUNDRED WAYS YOU CAN PREVENT IT FROM HAPPENING… FROM CHANGING THE DIET TO PLACING THEIR CAGE AT EYE LEVEL… IT IS CRAZY. BUT HUMANS ARE COMPLETELY DIFFERENT.

BetterCell says to AllieB2 (17:46):
IThere have not been any major breakthroughs for T1DM for a long time oththan Insulins with Depleted C-peptide.

Dr. Juan Bendala says to (17:46):
IN THE STEM CELL FIELD, THERE HAVE BEEN MANY

gina says (17:46):
my aunt was diagnosed with type 1 at 31

kerry says to (17:46):
The later the better… although it is harder to adjust mentally.

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BetterCell says to AllieB2 (17:47):
But not clinically, Dr. Bendala.

gina says (17:47):
tell me about it kerry!

Dr. Juan Bendala says to (17:47):
A YEAR AGO, THE FRIST COMPLETE PROTOCOL FOR ES CELL DIFFERENTIATION INTO BETA CELLS WAS PUBLISHED IN NATURE BIOTECH. THIS YEAR, THE FRIST STUDY TO RESET THE IMMUNE CLOCK WAS PUBLISHED. THESE STUDIES ARE STILL PRELIMINARY, BUT…

*** (17:47):Welcome to Dr. Juan Bendala Chat , piesconfort04 !

BadShoe says to (17:47):
so i should put the non D kids cage .. er.. rooms at eye level – ya learn something new every day

kerry says to (17:47):
Just to give us hope, in a ten year time frame, what do you see possibly ocurring?

Dr. Juan Bendala says to (17:48):
THEY ARE A FIRST STEP. WHILE CONTROVERSIAL, THE BRAZILIAN STUDY IS THE FIRST EVER TO REVERSE DIABETES. SOME PATIENTS ARE NOW RECURRING, BUT NOW WE HAVE A BASELINE TO IMPROVE UPON. AND WE WILL.

Dr. Juan Bendala says to (17:49):
IMAGINE IF YOU COULD RESET YOUR IMMUNE CLOCK TO A TIME PRIOR TO THE ONSET OF THE DISEASE, AND THEN GIVE YOUR PANCREAS A BOOST OF STEM CELL-DERIVED BETA CELLS. I SEE THAT HAPPENING IN THE NEXT 10 YEARS, CERTAINLY. IT WOULD BE MUCH CLOSER TO A CURE…

DRI CheerLeader says to (17:49):
I recall at least one of the Brazilian recipients was off insulin prior to the intervention…it’s been a long time since I read that study but I was not encouraged as I’m unwilling to have my child receive toxic immunosuppression with unknown long term re

DRI CheerLeader says to (17:49):
results

Dr. Juan Bendala says to (17:49):
THAN ANYTHING WE MAY HAVE ENVISIONED FIVE YEARS AGO.

Dr. Juan Bendala says to (17:50):
YES… THE BRAZILIAN STUDY USED A VERY TOXIC IMMUNOSUPPRESANT. WE ARE WORKING ON ALTERNATIVES. AT THE END OF THE DAY, YOU WANT THIS PROCEDURE TO BE SAFE.

gina says (17:50):
yea thats all we need diabetes and something else along with hit

gina says (17:50):
it

Dr. Juan Bendala says to (17:50):
ALL I CAN SAY IS THAT WE ARE WELL AWARE OF THE RISKS, BUT THE OVERALL PICTURE IS OPTIMISTIC.

kerry says to (17:51):
Sis was thinking you could transplant islet cells re the Brazilian therapy and since autoimmunity addressed… but of course since they are not the pt’s own islet cells, same problem?

Dr. Juan Bendala says to (17:51):
IN OUR LAB, WE HAVE DISCOVERED THAT OXYGEN ALONE, SOMETHING THAT WE BREATHE EVERY DAY, MAY BE INSTRUMENTAL IN GETTING AN UNLIMITED SUPPLY OPF BGETA CELLS FROM STEM CELLS.

Dr. Juan Bendala says to (17:51):
WE DIDN’T KNOW THAT TWO YEARS AGO! IT ALL ADDS UP.

*** (17:52):Welcome to Dr. Juan Bendala Chat , sstrumello !

kerry says to (17:52):
If a Dem gets elected, do you foresee broad leaps in your research? With federal funding. FINALLY……

kerry says to (17:53):
Getting the right person in the White House may be the most important thing right now.

BetterCell says to AllieB2 (17:53):
This has NOTHONG to do w/politics Kerry.

Dr. Juan Bendala says to (17:53):
THE IDEA WITH THE BRAZILIAN STUDY WOULD BE TO MAKE YOUR OWN INSULIN CELLS REGENERATE. OTHERWISE, WE COULD INFUSE NON-MATCHED ISLETS, WHICH MIGHT REQUIRE IMMUNOSUPPRESION. HOWEVER, IF WE PLACED THE ISLETS IN A SELF-CONTAINED DEVICE, IT WOULD BE LOCAL.

DRI CheerLeader says to (17:53):
Federal funding certainly has to do with politics.

kerry says to (17:53):
Federal Funding for embryonic stem cell research has everything to do with tonights topic, IMHO.

BadShoe says to (17:54):
yeah but I have heard the politic and I haven’t heard teh science

AllieB2 says to (17:54):
Politicians (both Dem and Rep) are driven by *big bucks* — “Big Bucks” come from Big Businesses..

Dr. Juan Bendala says to (17:54):
LET ME ASSURE YOU THAT WE’LL PURSUE THIS WORK WITH AND WITHOUT FEDERAL FUNDING. THE DRI, THANKS TO OUR FOUNDATION, IS NOT LIMITED. IT WOULD BE BETTER TO HAVE MORE MONEY, BUT OUR BENEFACTORS ARE MANY, AND OUR GOAL IS CLEAR.

AllieB2 says to (17:54):
and that might adversely affect any potential treatment that would **CURE** a disease like diabees 🙁

kerry says to (17:54):
MUST have Federal funding for embryonic stem cell research for Dr. Bendala’s research. Money = cure.

DRI CheerLeader says to (17:55):
And it would be better if you could comingle the research that is federally funded with that of your lab that is not.

sstrumello says to Dr. Juan Bendala (17:55):
What are your thoughts about Geron Corp. culturing beta cells in vitro that were responsive to blood glucose levels, something which failed in previous efforts&gt;

Dr. Juan Bendala says to (17:55):
THE LATTER IS COMPLICATED.

BetterCell says to AllieB2 (17:55):

Money does not=cure, science and intelligence and blessing does.

kerry says to (17:56):
And as I believe DRI scientist told me, while I was in the audience at Hyatt, many brilliant researchers will go into other areas of research because that is where the money is.

BadShoe says to (17:56):
Does the strain of stem cells make a differance

Dr. Juan Bendala says to (17:56):
THE GERON STUDY: WE PUBLISHED ONE YEAR EARLIER A VERY SIMILAR PROTOCOL, BUT FOR MOUSE EMBRYONIC STEM CELLS. AT THIS POINT WE ARE REPLICATING THE GERON STUDY IN OUR LAB. TOO EARLY TO SAY, BUT ON PAPER IT LOOKS PROMISING.

Dr. Juan Bendala says to (17:57):
THE STRAIN OF THE CELL DOES MAKE A DIFFERENCE. EVERY CELL LINE HAS A DIFFERENT BEHAVIOR

Dr. Juan Bendala says to (17:57):
WE NEED TO WORK WITH THE ONES THAT BEST END UP MAKING INSULIN.

BadShoe says to (17:57):
so is it likely that a strain that works in one case will not work in another

Dr. Juan Bendala says to (17:57):
OTHERS PREFER TO BECOME BRAIN TISSUE, OR MUSCLE.

DRI CheerLeader says to (17:58):
Do you have any contact with the Argentinian Dr. Vina who is also trying to use autologous stem cells for diabetes? I believe his research with cardiac cells was productive.

Dr. Juan Bendala says to (17:58):
YES, THAT’S ABSOLUTELY THE CASE, AND HAPPENS ALL THE TIME. THAT’S WHY WE NEED MANY CELL LINES.

*** (17:58):Welcome to Dr. Juan Bendala Chat , d !

sstrumello says to Dr. Juan Bendala (17:58):
Are mice studies terribly relevant, given the tremendous differences in cytoarchitechture between rodent and human beta cells?

Dr. Juan Bendala says to (17:58):
WE ARE COLLABORATING WITH DR ESTRADA, ALSO FROM ARGENTINA. HISD APPROACH LOOKS VERY PROMISING. DR VINA, HOWEVER, SEEMS TO BE… WELL, NOT VERY RIGOROUS.

BadShoe says to (17:58):
is there consistant behavior in a give stem line or is it YDMV (your diabetes may vary)

BadShoe says to (17:59):
given

Dr. Juan Bendala says to (17:59):
MOUSE STUDIES ARE RELEVANT, BUT ONLY TO CERTAIN EXTENT. IT IS A LIMITATION WE HAVE TO LIVE WITH.

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BetterCell says to AllieB2 (18:00):
NYC has lots of Rodents.

Dr. Juan Bendala says to (18:00):
STEM CELLS BEHAVE DIFFERENTLY DEPENDING ON MANY FACTORS. THE TECHNICIAN, FOR INSTANCE… AT TIMES, CULTURING THEM IS MORE AN ART THAN A SCIENCE.

DRI CheerLeader says to (18:00):
Do you collaborate at all with Doug Melton?

*** (18:00):Welcome to Dr. Juan Bendala Chat , StillTYpeI !

Dr. Juan Bendala says to (18:00):
MELTON IS A FOREMOST SCIENTIST IN THE AREA. WE DON’T HAVE ANY DIRECT COLLABORATION WITH HIM AT THIS TIME, BUT HE HAS SENT TO US SEVERAL HUMAN ES CELL LINES AND OTHER MATERIALS.

*** (18:01):Welcome to Dr. Juan Bendala Chat , d2095 !

Dr. Juan Bendala says to (18:02):
LET ME CONCLUDE WITH A FEW REMARKS. DIABETES IS A VERY COMPLEX DISEASE AND A CURE WON’T COME FROM ONE SINGLE MAGIC APPROACH. AT THE DRI, WE ARE FOCUSED ON TACKLING IT FROM ALL ITS DIFFERENT ANGLES.

gina says to Dr. Juan Bendala (private) (18:02):
Hey, Dr. Bendala the chat is over but if you want to still answer questions its up to you. if you can stay that is

*** (18:02):Welcome to Dr. Juan Bendala Chat , chelsea !

Dr. Juan Bendala says to (18:02):
PROGRESS IS VERY FAST. I DON’T THE ENTIRE FIELD OF “REGENERATIVE MEDICINE” WAS UNHERD OF 10 YEARS AGO…

DRI CheerLeader says to (18:03):
I wish you much success Dr. DB. You give us hope because there are dedicated researhers such as yourself who care enough to search for a cure. I for one am so grateful for your dedication.

gina says to Dr. Juan Bendala (18:03):
and me as well. Thank you for doing this chat!

sstrumello says to (18:04):
Thanks for chatting with us this evening Dr. Bendala!

kerry says to (18:04):

I as well. Thank you for your time and dedication.

Dr. Juan Bendala says to (18:04):
WE KEEP MAKING PROGRESS EVERY DAY, AND IT IS THE ADDITION OF EVERY LITTLE SUCCESS THAT GETS US CLOSER TO A CURE. THAT IT WILL HAPPEN, I HAVE NO QUESTION ABOUT IT. TO MAKE IT AVAILABLE TO EVERYBODY AS SOON AS SPOSSIBLE IS OUR PRIORITY.

BetterCell says to AllieB2 (18:04):
I am glad that you are Optimistic.

Dr. Juan Bendala says to (18:05):
I THANK YOU ALL FOR YOUR CONTINUOUS SUPPORT AND ENCOURAGEMENT. REST ASSURED THAT WE KEEP WORKING ON A CURE EVERY DAY. PLEASE COME VISIT US ANY TIME. JUST CALL OUR FOUNDATION AND THEY’LL ARRANGE A TOUR.

grossman9318 says to (18:05):
as a dri supporter i thank you all for this chat

sixuntilme says to (18:05):
Thanks for the informative chat.

DRI CheerLeader says to (18:05):
I hope to see the virtual tour of you and your lab on the DRI website

BadShoe says to (18:05):
Thanks

Dr. Juan Bendala says to (18:05):
IF YOU HAVE ANY ADDITIONAL QUESTIONS, YOU CAN E-MAIL ME AT [email protected]

kerry says to (18:05):
One of the most informative chats I’ve participated in. Thanks much.

gina says (18:05):
Thank you so much!

Dr. Juan Bendala says to (18:05):
Thank you all. Best

AllieB2 says to (18:05):
thank you, Dr. Bendala!! And Thank you, DRI!

*** (18:05):anderdn quit the room

gina says (18:05):
thanks DR. b

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kerry says to (18:06):
Wow. Thanks, Gina!

gina says (18:06):
This chat will be available on the DTF website t omorrow!

gina says (18:06):
kerry! thanks!

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gina says (18:06):
next chat is september 5

kerry says to (18:06):

Oh, yeah. I will print out a copy!

gina says (18:06):
with the makers of charmr

sstrumello says to (18:06):
Thanks, Gina … this was great … even though I stepped in pretty late … I can’t wait to see the transcript!

DRI CheerLeader says to (18:07):
Maybe Dr. DB could appear on DLife