March 13, 2013

Are T2Ds too sensitive?


too-sensitive_T2If you have T2D, you may be hypersensitive to C-reactive protein. This statement is based on findings in a new study. Is this a characteristic preempting T2D or is this something acquired after years of living with T2D?

C-reactive protein (CRP) is a measure of inflammation in the body. It binds to the surface of dead or dying cells. The levels of CRP are elevated in people with T2D. However, whether inflammation happens before or after the development of T2D is an important piece of the puzzle.

Cigarette smokers and obesity were independent of the results in this study. In other words, former smokers and obesity did not have a significant difference in CRP levels and diabetes development.

The study analyzed over 4,200 people for 6 years. These people were between 35 and 66 years of age. During the 6 year study, patients who had a higher level of CRP and continued to show chronic inflammation, were more likely to develop T2D. These findings were not significantly different in people that smoked or were obese.

Metaphorically speaking, the onset of T2D is like the mimosa pudica. It is one of the most sensitive plants in the world. Something about this plant allows its leaves  to fold inward and droop when shaken, and they reopen a few minutes later.

It would be nice if the human body did the same thing with the islet cells. In the event the islets are shaken,  they could close up, temporarily. They sort of do. They reopen for business, after the siesta. Unfortunately, often times there’s more work to be done and the islet morale gets burned-out, officially leadin to T2D.

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