November 22, 2013

Elevated Aldosterone in Metabolic Syndrome


aldoResearchers wanted to know what, if, and how aldosterone affects metabolic syndrome. Researchers undertook the task of evaluating the role of aldosterone in metabolic syndrome and published the results in Diabetes Research & Clinical Metabolism.

Aldosterone is a steroid hormone secreted by the adrenal glands. Aldosterone serves as the principal regulator of the salt and water balance of the body. It also has a small effect on the metabolism of fats, carbohydrates, and proteins. Does the level of aldosterone effect people with metabolic syndrome who are at an risk of increased cardiovascular complications?

It is possible to quantify the aldosteone levels by a simple blood test. Aldosterone increases the reabsorption of sodium and water and the release of potassium in the kidneys. This action raises blood pressure.

In the study, 46 people with metabolic syndrome and 25 healthy people had their BMI, waist circumference, blood pressure and heart rate (in office), 24-hour blood pressure monitoring, fasting blood sugar, lipid profile, and sodium & potassium, insulin, insulin resistance, plasma renin activity and aldesterone levels measured.

The results of the participants showed that aldesterone levels were significantly higher in people with metabolic syndrome but the plasma renin activity was not.  Heart rate was significantly increased in people with metabolic syndrome compared to healthy controls .

All of the other “not so good” measurements for BMI, blood pressure, heart rate, waist circumference, insulin resistance, and lipid profile were correlated to significantly higher levels of aldesterone.

It’s not so much about the muffin top as it is about the excess of aldosterone. It can be treated by first testing and adjusting sodium and potassium levels. If this does not help the next step would be to take medication.

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