September 16, 2013

Free Falling After 15 Years of T1D Without C-peptide


free-fallingNever have I been so taken aback by a hormone I don’t produce as I am with C-peptide. Almost every study related to c-peptide and T1D shows it plays an important role in the appearance of diabetes complications. A study in the Journal of Korean Medical Science shows how vitally important and curiosity absent it is at 15 years of T1D.

This study was done to characterize the natural course of C-peptide levels in people with T1D. Over a 15 year period, 95 children with T1D were studied to measure their levels of C-peptide,  HbA1c, weight, BMI, and diabetic complications.

Researchers wanted to see if there were significant differences with higher levels of C-peptide, compared to people with lower levels of C-peptide.

After 15 years of T1D, the C-peptide level measurements were significantly reduced in all patients, from diagnosis.  The incidence of DKA was remarkably less in patients with higher levels of C-peptide.

The more insulin your body needs to regulate itself, the more body weight you may have. Injected insulin needs are higher because the subcutaneous fat absorbs some of the insulin. The body weight and BMI, 15 years after diagnosis were significantly higher among the patients with low C-peptide levels.

A parachutte breaks the fall when you skydive. In a strange way, there is a correlation to C-peptide in T1D. Without C-peptide, after 15 years of T1D, people with T1D are free falling without any protection from complications.

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