May 8, 2013

Genes Overexpressed in T1D Peripheral Complications


expressionsThe study published in Diabetes Care has identified the upregulation of genes responsible for T1D and its complications.

Some genes are expressed differently in people with T1D and islet autoantibods. In this study, these genes were examined for the role they play in the development of T1D complications.

Patients enrolled in the study included 928 people with T1D and 922 control subjects. The study evaluated 18 genes, total. Of the genes studied, 8 had higher expression and 3 genes had lower expression in people with T1D, compared with control subjects.

The higher expression genes seemed to be genes involved in inflammation, immune regulation, and antigen processing. These genes are significantly altered in people with T1D in the PBMG, or peripheral blood mononuclear cells.

The 8 troublemakers implicated in diabetes and its complications are: S100A8,  S100A9,  MNDA, SELL,  TGFB1,  PSMB3,  CD74, and IL12A. So if you have T1D and peripheral complications, chances are these guys are crashing the party.

SELL, along with 3 other inflammatory genes mainly were significantly higher in T1D patients with complications, especially those people with neuropathy.

On the outside, anybody walking on the street can look unsuspecting. In fact, they may be able to pass a lie detector test. But imagine what you could learn about a person if you could profile their genes? No secrets here.

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