September 23, 2013

Types of Neuropathy 40 years with T1D


fibersAsking somebody to put themselves in your shoes takes on a whole different meaning if you have small or large fiber neuropathy, 40 years with T1D. A study published in Diabetes Care explains the difference and how it could impact the meaning of that statement.

Peripheral neuropathy involve different types of nerve fibers. Large fiber neuropathy is the numbness, tingling, and weakness in the arms and feet. Small fiber neuropathy involves severe pain  in the limbs.

In this study, large- and small-nerve fiber function in people with long-term T1D were evaluated for their HbA1c and G1A or advanced glycation end products.

Evaluating people with T1D for almost 40 years, researchers wanted to see if there was a significant association between the HbA1c levels, AGES, and type of sensory neuropathy resulting from T1D.

Of the study participants, almost 60% had large-fiber neuropathy. Over 80% had small-fiber dysfunction. The heat pain threshold in the foot were associated with HbA1c.

Small-fiber sensory neuropathy is quite evident in people with T1D for 40 years. HbA1c and the AGEs are important risk factors in the development of large- and small-fiber dysfunction in long-term T1D.

Although it seems obvious to me, why isn’t c-peptide a measurement in these people with long-term T1D and neuropathy. Studies have shown, time after time, that c-peptide replacement corrects and minimizes diabetes neuropathy. Thank you, Cebix,

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