January 3, 2014

What Lurks in Fat Cells?


fat-cellsObesity isn’t pretty on any canvas and the dirty little cause of such inflammation is identified by a study published in Cell Metabolism. These freeloaders are more like fat loaders because they bloat the fat tissues.

Fatt cells don’t strike me as a cozy places to snuggle and multiply but macrophages disagree. Apparently they thrive and undergo cell division in adipose tissue. This is what the study has found in mice.

More interesting is that obesity increases the proliferation of macrophages in fat cells but not other tissues. Perhaps these unfriendly looking bulges are quite warm and cozy for macrophages, after all.

Recruitment of monocytes is essential for effective control and clearance of viral, bacterial, fungal and protozoal infection. This study found that macrophage proliferation occurs independently of monocyte recruitment, alluding to the macroogage growth occuring like an antibiotic-resistant bacteria.

How does this all happen? MCP-1 regulates migration and infiltration of monocytes/macrophages in cells. MCP-1 stimulates macrophage cell division in adipose tissue.

The combination of a specific protein and a malfunctioning processes in fat cells, secondary inflammation is stirred by macrophages in an unorthodox manner. Abnormal growth in the human body is never a good thing.

If you downsize the real estate, aka fat cells, the abnormal process, protein, and macrophages cannot cause their trouble in your temple. It’s easier said than done but it’s worth a try signing-up with Weight Watchers in the new year.

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