September 24, 2013

Yo Yo GABA GABA for Beta Cell Survival


yo-gaaSounds fun if you look at it that way, but the neurotransmitter GABA may be a promising new therapy for improving beta cell survival after an islet cell transplant and increasing beta cell growth  in patients with diabetes. The study was published in Diabetes.

GABA is an inhibitory neurotransmitter. It has been found to relieve anxiety and calm easily excitable people. In this study, GABAA receptors significantly inhibits beta cell death resulting from oxidative stress and preserves beta cells.

A major hurdle in beta cell transplantations is being able to encourage the survval of these delicate cells once in the new body. Researchers found that treatment of GABA aided beta cell survival and promoted beta cell duplication in an subjects with high blood sugar.

The findings of this study were of particular interest because often times when a treatment is found to have success in rodent models, it does not translate into humans. This study found that GABA was successful with transplanted human beta cells.

Yo yo Gaba Gaba is fun, DJ Lance Rock is the man. I like to dance. But all joking aside, GABA in the non-Nick Jr. perspective serves a two-fold approach by regulating the survival and replication of human beta cells and this may be encourages by the anti-inflammatory properties of GABA.

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